Amlodipine pinpoint rash skin#
An aeroallergen skin test and food allergy skin test were performed, results of which did not show any significant sensitization. A skin biopsy was performed and sent for evaluation. He was prescribed H1- and H2-antagonists, as well as a tapering course of prednisone. The amlodipine was discontinued and replaced with hydrochlorothiazide. Neither mucous membrane involvement nor systemic symptoms were reported. The skin in between each lesion was clear (Figure 1). Multiple discrete discoid, erythematous, maculopapular patches with fine scales covered most of the back. At the time of onset of the rash, the patient had taken levothyroxine, pravastatin, omeprazole, metoprolol, and amlodipine. The patient had been living by himself, denied use of new soaps or detergents, denied use of lotions or creams, and denied any other recent skin lesions, atopic symptoms, or urticaria. He experienced little improvement of his symptoms and was referred by his primary care physician for further allergy evaluation, where he presented to our clinic. Two steroid injections were administered at an urgent care clinic 1 day apart, and the patient was started on methylprednisolone. Three days after initiating treatment, he developed an extremely pruritic rash on his back. Sanaa Mahmoud, MD, PhD, University of Pikeville-Kentucky College of Osteopathic Medicine, 147 Sycamore Street, Pikeville, Kentucky 41501 ( 63-year-old man with hypertension was prescribed amlodipine for blood pressure control. The authors report no relevant financial relationships. Accepted August 30, 2021. Published online February 2, 2022. Amlodipine-induced eczematous drug eruption. Accessed May 18, 2021.1Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai, New York, New YorkĢResearch Fellow, Department of Pediatrics, Ains Shams University, EgyptģUniversity of Pikeville-Kentucky College of Osteopathic Medicine, Pikeville, KentuckyĤFaculty of Medicine, Ains Shams University, EgyptĥLincoln Memorial University-DeBusk College of Osteopathic Medicine, Harrogate, TennesseeĪli A, Mahmoud S, Nguyen J. Henoch-Schonlein purpura (IgA vasculitis): Rapid evidence review. IgA vasculitis (Henoch-Schonlein purpura): Management. IgA vasculitis (Henoch-Schonlein purpura): Clinical manifestations and diagnosis. National Institute of Diabetes and Digestive and Kidney Diseases. Usually this goes away once the illness passes, but some people develop persistent kidney disease.
In most cases, this shows up as protein or blood in the urine, which you may not even know is there unless you have a urine test done. Henoch-Schonlein purpura can also affect the kidneys. These symptoms sometimes occur before the rash appears.
Many children with Henoch-Schonlein purpura develop belly pain, nausea, vomiting and bloody stools.
These symptoms subside when the disease clears and leave no lasting damage. Joint pain sometimes precedes the classical rash by one or two weeks. People with Henoch-Schonlein purpura often have pain and swelling around the joints - mainly in the knees and ankles. The rash can also appear on the arms, face and trunk and may be worse in areas of pressure, such as the sock line and waistline. Reddish-purple spots that look like bruises develop on the buttocks, legs and feet. The four main characteristics of Henoch-Schonlein purpura include:
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